循环快速眼动睡眠表达与老年人大脑微观结构完整性有关
Michele Deantoni1, Mathilde Reyt1,2, Marine Dourte1,2
1GIGA-CRC Human Imaging, University of Liège, Liège, Belgium.
Communications biology
|June 22, 2024
概括
快速眼动睡眠 (REMS) 的昼夜幅度降低与老年人白色和灰色物质的变化有关. 这表明昼夜调节对于理解大脑衰老和睡眠结构很重要.
科学领域:
- 神经科学是一个神经科学.
- 睡眠科学 睡眠科学
- 老年学是一门学科.
背景情况:
- 快速眼动睡眠 (REMS) 显示了与年龄相关的神经退行症的微妙迹象.
- 循环节律失调随着年龄的增长而增加,但其与大脑衰老和REMS调节的联系尚不清楚.
研究的目的:
- 评估大脑衰老与REMS的昼夜调节之间的关联.
- 为了研究大脑微观结构完整性与老年人昼夜REMS振幅的关系.
主要方法:
- 使用40小时实验室多次午睡协议测量昼夜REMS振幅.
- 在86名老年人中通过定量多参数映射 (MPM) 成像评估大脑微观结构完整性.
主要成果:
- 降低昼夜REMS振幅与侧腔室附近白质中较低的MTsat,R1和R2*值相关.
- 在灰色物质区域观察到较低的R1值,包括海马体,准海马体, thalamus 和 hypothalamus.
结论:
- REMS的循环调节与老年人的大脑微观结构完整性有关.
- 考虑昼夜节律对于理解睡眠与老化中的大脑结构之间的关系至关重要.
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