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Updated: Jun 23, 2025

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
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在evolocumab和alirocumab试验中对基线失衡的定量评估:一项超流行病学研究

F H van Bruggen1, S U Zuidema1, H J Luijendijk2

  • 1Department of General Practice and Elderly Care Medicine, University of Groningen, University Medical Centre Groningen (UMCG), PO Box 196, Groningen, AD, 9700, The Netherlands.

BMC medical research methodology
|June 22, 2024
PubMed
概括

随机试验的PCSK9抑制剂如evolocumab和alirocumab经常有基线失衡. 患者特征中的这些差异可能会影响研究结果,并引起对随机化程序的担忧.

关键词:
基线不平衡的基本情况这是一个偏见的偏见.超回归是指元回归.PCSK9 抑制剂的使用.

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Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
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