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与癌症相关的lncRNAs在不同亚型的垂体腺瘤中的差异表达

Farbod Esfandi¹, Seyed Amirmohsen Mirjafari², Negar Rezazadeh³

¹Department of Microbial Biotechnology, School of Biology and Center of Excellence in Phylogeny of Living Organisms, College of Science, University of Tehran, Tehran, Iran.

Pathology, research and practice

|June 23, 2024

概括

像HOTTIP,PANDAR和ANRIL这样的长非编码RNA (lncRNAs) 在垂体腺瘤中显示出改变的表达. 这表明它们在瘤发育中的潜在作用,需要进一步调查.

科学领域:

内分泌学在内分泌学.
分子生物学分子生物学
在瘤学瘤学.

背景情况:

垂体腺瘤是常见的瘤,不完全理解病原体.
在各种癌症中观察到非编码RNA (ncRNA) 的异常表达,包括垂体腺瘤.
许多长非编码RNAs (lncRNAs) 在垂体瘤发育中的特定作用仍然在很大程度上未被阐明.

研究的目的:

为了研究与相邻的非瘤垂体组织相比,垂体腺瘤中选择的lncRNAs (HOTTIP,ANRIL,PANDAR,PCGEM1,HOTAIR) 的表达水平.
评估这些lncRNAs对垂体腺瘤病变的潜在贡献.

主要方法:

使用定量实时PCR来测量HOTTIP,ANRIL,PANDAR,PCGEM1和HOTAIR的表达.
在垂体腺瘤样本 (包括非功能性垂体腺瘤 - NFPA) 和配对的正常垂体组织之间进行了表达水平的比较.

主要成果:

在大多数样本中,HOTAIR表达是可以忽略的.
在非功能性垂体腺瘤 (NFPA) 样本与正常组织 (p=0.03) 中,HOTTIP表达显著升高.
与正常组织相比,在总腺瘤样本中,PANDAR表达显着更高 (p=0.02).
与正常组织相比,ANRIL表达在NFPA样本 (p=0.048) 和总腺瘤样本 (p=0.025) 中显著上调.

结论:

这些发现表明,lncRNAs,特别是HOTTIP,PANDAR和ANRIL,在垂体腺瘤中表达不同.
这些lncRNAs可能在某些垂体腺瘤亚型的发病过程中发挥作用.
需要进一步的功能性研究来阐明这些lncRNAs对垂体瘤发展的贡献的确切机制.

关键词:

生物标志物生物标志物诊断诊断诊断的诊断表达方式表达方式表达方式表达方式表达方式表达方式表达方式表达方式表达方式表达方式表达方式表达方式表达方式这是一个LncRNARNA.下垂体腺瘤是什么意思

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