双A暴露与心脏代谢结果之间的关联:纵向方法
Sofia Almeida Costa1, Milton Severo2, Carla Lopes3
1EPIUnit - Instituto de Saúde Pública, Universidade do Porto, Rua das Taipas, n° 135, Porto 4050-600, Portugal; Laboratório para a Investigação Integrativa e Translacional em Saúde Populacional (ITR), Universidade do Porto, Rua das Taipas, n° 135, Porto 4050-600, Portugal.
暴露在食品包装中发现的内分泌干扰物双甲 (BPA) 与儿童和青少年胰岛素,胰岛素抵抗和肥胖标志物增加有关. 减少早期BPA暴露对长期心脏代谢健康至关重要.
科学领域:
- 环境健康 环境健康
- 内分泌学 在内分泌学.
- 儿科健康 儿科健康
背景情况:
- 心脏代谢风险与改变的生物标志物概况和脂肪性有关.
- 内分泌干扰化学物质 (EDC) 从生命早期就会对心脏代谢健康产生负面影响.
- 双A (BPA) 是一种常见的食品污染物和食品接触材料中发现的EDC.
研究的目的:
- 纵向评估双A (BPA) 暴露与心脏代谢结果之间的关联.
- 为了研究BPA对葡萄牙出生队伍的胰岛素水平,胰岛素抵抗和脂肪的影响.
- 检查BPA暴露和从童年到青春期的健康指标之间的横截面和纵向关系.
主要方法:
- 利用了葡萄牙人口基出生队列的数据21世纪一代.
- 纵向评估了每日BPA暴露与心脏代谢结果之间的关联.
- 对包括能量摄入在内的相关变量进行调整分析.
主要成果:
- 在BPA暴露和增加血液中的胰岛素和胰岛素抵抗之间发现了显著的纵向关联.
- 暴露于BPA与较高的脂肪质量百分比和腰围在纵向上显著相关.
- 对z-BMI与BPA暴露观察到显著的横截面和纵向关联.
结论:
- 这是第一个评估从童年到青春期BPA暴露和健康结果的研究.
- 暴露于BPA与不良的心脏代谢标志物有关,包括胰岛素升高,胰岛素抵抗和脂肪增加.
- 这些发现强调了在早期发育阶段尽量减少BPA暴露的重要性,以保护长期健康.
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