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眼科疹复发:危险因素和长期临床结果

Daniel A R Scott¹, Kevin Liu¹, Helen V Danesh-Meyer¹

¹From the Department of Ophthalmology (D.A.R.S., K.L., H.V.D.-M., R.L.N.), Greenlane Clinical Centre, Te Whatu Ora Health New Zealand, Auckland, New Zealand; Department of Ophthalmology, University of Auckland, Auckland, New Zealand.

American journal of ophthalmology

|June 23, 2024

概括

疹子眼睛疾病 (HZO) 的复发是常见的,增加视力损失的风险. 密切监测至关重要,特别是在局部类固醇停止后,以及那些有风险因素的人.

科学领域:

眼科医生眼科眼科
传染性疾病传染性疾病

背景情况:

疹眼 (Herpes zoster ophthalmicus,简称HZO) 是影响眼神经的水病毒的重新激活.
HZO可以导致严重的眼部并发症和视力受损.

研究的目的:

为了确定HZO眼病的复发率.
为了确定与HZO复发相关的风险因素.
评估HZO患者的长期临床结果,包括视力丧失.

主要方法:

追溯队列研究包括869名急性HZO患者从2006年至2016年.
主要结局:眼部疾病复发. 二次结局:中度视力丧失 (视力敏度≤20/50).
风险因素的分析,包括免疫抑制,眼内压力和角膜/脑膜干扰.

主要成果:

23.0%的患者至少出现过一次复发,平均时间到第一次复发为3.5个月.
复发预测因素包括免疫抑制,眼内压升高,角膜干扰和脑膜炎.
视力丧失随着复发次数的增加而增加,影响57.4%的眼睛有四次或更多的复发.

结论:

HZO眼病的复发频繁,并与逐渐的视力丧失有关.
识别和监测患有复发风险因素的患者至关重要.
在停止局部类固醇治疗后需要特别警,因为中位复发时间为1.4个月.

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