初级运动皮层的跨体磁性刺激会引起一个即时的跨体唤起的潜力
Mikkel Malling Beck1, Lasse Christiansen2, Mads Alexander Just Madsen1
1Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark.
研究人员使用高密度脑电图 (EEG) 确定了对跨磁刺激 (TMS) 的立即多峰皮质反应. 这些发现表明运动皮层中存在真正的神经活动,而不是人工物.
科学领域:
- 神经科学是一个神经科学.
- 电子生理学 电子生理学
- 大脑刺激 大脑刺激
背景情况:
- 通过脑电图 (EEG) 测量的跨脑唤起潜力 (TEP) 对于理解皮质对跨脑磁刺激 (TMS) 的反应至关重要.
- 即时TEPs (i-TEPs) 经常被人工物掩盖,导致报告的延迟时间太长,无法反映直接的神经刺激.
研究的目的:
- 为了调查TMS的真实即时皮质反应.
- 为了克服i-TEP记录中工件污染的局限性.
主要方法:
- 在25名健康个体中记录了i-TEP,使用高采样率EEG (50kHz) 单脉冲TMS针对主动手部区域 (M1HAND) 或对照区域.
- 将TMS脉冲工件最小化为几毫秒,并通过精确的线圈定位避免肌肉工件.
主要成果:
- 观察到一个早期的阳性EEG偏移 (大约. 2毫秒的延迟),然后在感觉运动皮层周围叠加的峰值 (1.11.4毫秒间隔).
- 这种多峰期i-TEP反应是特定于M1刺激的,对刺激强度和电流方向敏感.
结论:
- M1HAND的单脉冲TMS引起了快速的,局部化的多峰反应,表明了真正的皮质活动.
- 这一发现表明,前中心皮层中金字塔神经元的同步激发需要进一步验证,以排除残留人工物.
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