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皮肤白色脂肪组织衍生的Il-33调节炎症期间髓状细胞中的Il-4/13表达

Anastasia Ertel¹, Ulf Anderegg¹, Sandra Franz¹

¹Department of Dermatology, Venereology and Allergology, University of Leipzig Medical Center, Leipzig, Germany.

The Journal of investigative dermatology

|June 23, 2024

概括

皮肤白色脂肪组织 (dWAT) 在皮肤炎症期间释放IL-33,刺激骨髓细胞产生IL-4/13,有助于解决炎症. 肥胖会破坏这种IL-33-IL-4/13级联,可能会延长炎症.

科学领域:

免疫学免疫学免疫学
皮肤病学皮肤病学
代谢过程中的代谢.

背景情况:

皮肤白色脂肪组织 (dWAT) 除了储能之外,还具有新兴的免疫调节作用.
关于dWAT在皮肤炎症控制中的作用的数据有限.
了解dWAT的免疫功能对于炎症性皮肤疾病至关重要.

研究的目的:

研究dWAT在急性皮肤炎症中的作用.
阐明dWAT影响皮肤免疫反应的机制.
探索肥胖对dWAT介导的免疫调节的影响.

主要方法:

在模型系统中诱导急性皮肤炎症.
皮肤白色脂肪组织 (dWAT) 的激活和媒介分析.
在髓状细胞中的基因表达分析 (Il4,Il13).
研究介素-33 (IL-33) 信号传递.

主要成果:

激活的dWAT释放出可溶性介质,这些介质在髓状细胞中对Il4和Il13进行上调.
炎症皮肤中的髓状细胞显示增加了Il-4/13表达.
从dWAT中释放的介质蛋白-33 (IL-33) 驱动这种IL-4/13刺激.
肥胖会影响dWAT中的IL-33分泌,从而降低IL-4/13的表达.

结论:

dWAT启动了一种依赖IL-33的IL-4/13信号级联,有助于炎症解决.
这种dWAT驱动的级联运行独立于T助手2细胞.
肥胖会破坏这种保护机制,可能导致慢性炎症.

关键词:

这里有IL-33和IL-33.炎症炎症是一种炎症.骨髓状细胞是骨髓状细胞.肥胖问题肥胖问题 dWAT dWAT 在线播放

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