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低海拔和高海拔山羊的基因表达和肠道微生物群组成差异

Zhenzhen Zhang¹, Xin Zhang¹, Tingting Zhang²

¹College of Life Sciences and Engineering, Southwest University of Science and Technology, Mianyang, Sichuan 621000, China.

|June 23, 2024

概括

高海拔对雄性山羊的生育能力产生负面影响,因为它减少了丸的大小并损害了精子的生产. 肠道微生物群的变化和丸基因表达的改变有助于这种生殖能力的下降.

科学领域:

生殖生物学生殖生物学
环境生理学环境生理学
微生物组研究微生物组研究

背景情况:

以前的研究表明,高度对生殖过程产生负面影响,但机制尚不清楚.
了解这些影响对于高海拔地区的牲畜管理至关重要.

研究的目的:

为了研究高海拔对雄性山羊生殖参数的影响.
阐明影响高海拔地区生育能力的潜在分子和微生物机制.

主要方法:

从低高度和高高度的山羊中对丸mRNA概况 (RNA-seq) 和肠道微生物群组成 (16S rDNA测序) 的比较分析.
对丸大小的分析和差异表达基因 (DEGs) 的鉴定.

主要成果:

高海拔山羊的丸尺寸有所减少.
在丸中发现了214个DEG,与免疫抑制减弱和精子生成受损有关.
在高度组之间观察到肠道微生物属 (例如,Treponema,Desulfovibrio) 的显著差异.
肠道微生物群和丸功能在降低生育能力方面发挥了协同作用.

结论:

高海拔地区通过减少丸大小,改变基因表达和肠道微生物群的变化,损害雄性山羊的生育能力.
肠-丸轴在山羊的高度诱导的生殖能力下降中发挥着关键作用.
这些发现为未来关于雄性山羊在不同海拔高度的生殖能力的研究提供了基础.

关键词:

高度高度的高度.一只山羊是一只山羊.我们的肠道微生物群.生殖健康繁殖健康协同作用协同作用测试 (Testis) 是一个测试.

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