在前性队列研究中,怀孕期间的颗粒物暴露与幼儿的执行功能之间的关联
Lei Zhang1, Yuanyuan Zhu1, Haixia Wang1
1Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, China; MOE Key Laboratory of Population Health Across Life Cycle, Hefei, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, China; Anhui Provincial Key Laboratory of Environment and Population Health across the Life Course, Anhui Medical University, Hefei, China.
Environmental research
|June 23, 2024
概括
产前暴露于细颗粒物 (PM) 与婴儿执行功能 (EF) 较差有关. 哺乳可能会对这些不良影响产生保护作用.
科学领域:
- 环境健康 环境健康
- 发展心理学 发展心理学
- 儿科 儿科 儿科
背景情况:
- 对颗粒物 (PM) 的暴露与认知障碍有关.
- 有限的研究存在于产前PM暴露和幼儿执行功能 (EF).
- 在这种情况下,母乳养的潜在保护作用尚未得到充分研究.
研究的目的:
- 调查产前暴露于PM (PM1,PM2.5,PM10) 和幼儿执行功能之间的关联.
- 探索母乳养时间对产前PM暴露和幼儿EF之间的关系的潜在缓解效应.
主要方法:
- 在2015-2019年期间,招募了1106对母婴.
- 估计了母亲对PM1,PM2.5和PM10的产前暴露,使用由住宅地址分配的基于卫星的数据集 (1x1km分辨率).
- 幼儿EF使用学前儿童执行功能行为评分清单 (BRIEF-P) 问卷进行评估.
主要成果:
- 第一个季度增加的PM1,PM2.5和PM10暴露与婴儿全球执行综合指数得分较高 (EF较差) 相关.
- 第一个三个月的PM1暴露与哺乳期小于6个月的幼儿的抑制得分较高有关,但未与哺乳期≥6个月的幼儿相关 (P=0.046).
- 第一季度的PM1暴露与哺乳期<12个月的幼儿的情绪控制得分较高,以及哺乳期≥12个月的幼儿的抑制得分较高 (P=0.043).
结论:
- 孕前暴露于PM,特别是PM1,在头三个月期间与幼儿执行功能下降有关.
- 哺乳,特别是长时间的哺乳,可以作为一种保护因素,防止产前PM暴露对幼儿的负面影响.
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