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Updated: Aug 6, 2026

Analysis of Single-cell Gene Transcription by RNA Fluorescent In Situ Hybridization FISH
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Analysis of Single-cell Gene Transcription by RNA Fluorescent In Situ Hybridization FISH

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解读了Plasmodium falciparum核周变异基因表达部位的解读

Gretchen Diffendall1, Artur Scherf1

  • 1Institut Pasteur, Universite Paris Cité, INSERM U1201, CNRS EMR9195, Paris, France.

Trends in parasitology
|June 23, 2024
PubMed
概括

疟疾寄生虫Plasmodium falciparum通过一次只表达一个 var 基因来逃避免疫反应. 本研究探讨了涉及这一关键毒性机制的周核表达部位 (PES) 和调节性RNA.

关键词:
在P. falciparum的研究中.抗原变异是一种抗原变异.疟疾 疟疾 是一种疾病.周核表达部位是周核表达部位.监管性的非编码RNA.

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In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
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