在竞争风险的生存分析中,分发危险比率和因果特异性危险比率之间的罕见事件近似值
1Department of Clinical Biostatistics, Graduate School of Medicine, Kyoto University.
Journal of epidemiology
|June 23, 2024
概括
了解研究中的竞争性风险至关重要. 这项研究阐明了分发危险比率和因果特定危险比率之间的区别,提供了它们的转换方法,并有助于样本大小计算.
科学领域:
- 流行病学 流行病学
- 临床试验 临床试验
- 生物统计学 生物统计学
背景情况:
- 在流行病学和临床研究中,相互竞争的风险是常见的.
- 在将竞争风险视为审查与分发风险比率时,危险比率之间的区别经常被忽视.
研究的目的:
- 导出分发危险比率和因果特定危险比率之间的定量关系.
- 开发一种近似的计算方法,用于在这两种危险比率类型之间进行转换.
- 为这些计算在研究环境中提供实际应用.
主要方法:
- 在分发危险比率和因果特异性危险比率之间推导的定量关系.
- 开发了一种用于相互转换的近似计算方法.
- 使用假设场景的验证方法,降胆固醇治疗试验和急性髓性白血病登记.
主要成果:
- 根据罕见事件假设,在细分分布和因果特异性危险比率之间建立了一般和近似的关系.
- 提出了一个基于生存率的近似公式.
- 证明了两种应用:从现有数据计算分发危险比率,并为计算竞争风险的样本大小估计提供信息.
结论:
- 危险比率类型之间的区别是通过考虑感兴趣的事件和竞争风险的稀有性,以及生存率来澄清的.
- 开发的近似公式在具有竞争风险的流行病学和临床研究中具有实际实用性.
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