孕期糖尿病和怀孕中的C反应性蛋白/白蛋白比:一项前性研究
Eda Ureyen Ozdemir1, Gul Nihal Buyuk2, Esin Merve Erol Koc1
1Department of Obstetrics and Gynecology, Ministry of Health Ankara City Hospital, Ankara, Turkey.
Yonsei medical journal
|June 24, 2024
概括
反应蛋白/白蛋白比率 (CAR) 是一种简单,廉价的标志物,在妊娠期糖尿病 (GDM) 的怀孕中显著上升. 汽车是GDM发展的独立预测器.
科学领域:
- 产科和妇科 产科和妇科
- 临床化学 临床化学
- 炎症标志物 炎症标志物
背景情况:
- 反应性C蛋白/白蛋白比率 (CAR) 被公认为一种新的炎症标志物.
- 炎症在各种妊娠并发症中起作用.
研究的目的:
- 评估和比较C-反应性蛋白/白蛋白比率 (CAR) 在怀孕和没有妊娠糖尿病 (GDM) 的孕妇中的水平.
- 评估CAR作为GDM潜在的炎症标志物.
主要方法:
- 一项前性病例控制研究包括810名接受例行产前查的孕妇.
- 参与者被分为GDM阳性和GDM阴性组.
- 在两组之间统计比较了CAR水平.
主要成果:
- 与健康对照组相比,GDM组的CAR值显著增加 (1.07与0.37,p<0.0001).
- CAR与口服葡萄糖耐受性测试的所有阶段 (p<0.0001) 和中性粒细胞与淋巴细胞的比率 (p=0.011) 显示出显著的正相关性.
结论:
- CAR是一种临床上可访问和廉价的GDM发展的独立预测器.
- 这项研究是首次强调CAR在GDM中的作用.
- 建议进行进一步的大规模研究以验证这些发现.
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