在患有贫血的儿童口服铁疗法的反应中,肝素水平
Tanya Singh1, Shilpa Khanna Arora2, Parul Goyal3
1Department of Pediatrics, Atal Bihari Vajpayee Institute of Medical Sciences and Dr Ram Manohar Lohia Hospital, Baba Kharag Singh Marg, New Delhi, India.
Indian pediatrics
|June 24, 2024
概括
在患有缺铁性贫血的儿童开始口服铁疗法后24小时内,血清肝素水平迅速增加. 肝素的这种早期上升表明,它有可能成为治疗反应的指标.
科学领域:
- 生物化学 生物化学
- 儿科血液学 儿科血液学
- 营养科学 营养科学
背景情况:
- 缺铁性贫血 (IDA) 是儿童普遍存在的全球健康问题.
- 肝素是铁代谢的关键调节剂,其在缺铁性贫血中的水平通常很低.
- 了解铁补充期间的肝素动态对于优化治疗策略至关重要.
研究的目的:
- 为了评估血清肝素-25水平的变化,在口服铁治疗的前两个星期,在儿童患者与IDA.
- 为了研究血清肝素-25水平变化和血红蛋白 (Hb) 水平变化对口服铁治疗的反应之间的相关性.
主要方法:
- 一项前性观察性研究包括64名被诊断患有IDA的2-12岁儿童.
- 排除标准包括严重的贫血,感染,最近的铁摄入量或输血.
- 血清肝素-25在基线,24小时和开始口服铁疗法后14天使用ELISA进行测量.
主要成果:
- 血清海普西丁-25水平显著比起起始值 (7.81 ng/mL) 在24小时 (8.38 ng/mL) 和14天 (9.51 ng/mL) 的口服铁疗法显著增加 (P < 0.001).
- 在64名儿童中,在63名儿童中观察到口服铁的良好治疗反应.
- 在基线肝素水平和血红蛋白在第1天 (r = -0.10,P = 0.40) 或第14天 (r = -0.10,P = 0.43) 的变化之间没有发现显著的相关性.
结论:
- 口服铁疗法导致IDA儿童的血清肝素水平显著且快速增加,可在24小时内检测到.
- 血清肝素的早期升高需要进一步调查,作为评估小儿贫血中口服铁疗法的反应的潜在生物标志物.
- 肝素的动态提供了关于治疗期间身体对铁的调节反应的见解.
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