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Updated: Jun 23, 2025

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
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Published on: January 16, 2016

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利用酶催化中的构造动态来实现与自然相似的催化效率:用于计算性酶重新设计的最短路径图工具

Cristina Duran1, Guillem Casadevall1, Sílvia Osuna1,2

  • 1Departament de Química, Institut de Química Computacional i Catàlisi, Universitat de Girona, c/Maria Aurèlia Capmany 69, 17003, Girona, Spain. silvia.osuna@udg.edu.

Faraday discussions
|June 24, 2024
PubMed
概括

最短路径图 (SPM) 方法与基于模板的AlphaFold2分子动力学 (tAF2-MD) 结合,有效地预测了酶结构变化. 这种方法可以识别用于计算酶工程的关键突变部位.

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