在全身性硬化症的胃肠道表现中Helicobacter pylori
Jasmin Raja1, Shanthini Muthusamy1, Choung Min Ng2
1Division of Rheumatology, Department of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.
Journal of scleroderma and related disorders
|June 24, 2024
概括
在全身性硬化症患者中,Helicobacter pylori感染不常见,并且不会显著恶化胃肠道症状. 根除H. pylori可以改善这些患者的消化问题.
科学领域:
- 胃肠病学 胃肠病学
- 类风湿病学 类风湿病学
- 微生物学 微生物学
背景情况:
- 系统性硬化症 (SSc) 是一种多系统的自身免疫性疾病,其特点是纤维化,血管功能障碍和免疫失调.
- 胃肠道 (GI) 症状在SSc中很常见,严重影响生活质量.
- 杆菌 (H. pylori) 感染在SSc相关的胃肠道症状中的作用尚不清楚.
研究的目的:
- 为了确定系统性硬化症患者中H. pylori感染的患病率.
- 为了比较H. pylori阳性和H. pylori阴性SSc患者之间的GI表现.
- 在SSc患者中评估H. pylori根除疗法后的GI结果.
主要方法:
- 70名SSc患者和70名匹配的健康对照进行了尿素呼吸测试 (UBT) 以检测H. pylori.
- 用加利福尼亚大学洛杉矶分校 (UCLA) 2.0和利兹消化不良问卷 (LDQ) 来评估消化不良症状.
- 怀有H. pylori阳性的SSc患者接受了根除疗法,随后在6周后重复UBT和症状再评估.
主要成果:
- 在SSc患者 (10%) 和健康对照组 (2.9%) 中,H. pylori的患病率较低,没有显著差异.
- 在H.pylori阳性和H.pylori阴性SSc患者之间没有观察到整体胃肠道症状的显著差异.
- 阳性H. pylori患者报告了反流,腹部张张和社会功能障碍 (UCLA 2.0) 的中位数严重性得分较高,腹部上部疼痛,吐和吐 (LDQ) 的增加.
- 根除后的胃肠道结局显示,H. pylori阳性患者的症状有所改善或完全消失.
结论:
- 在这个SSc患者队列中,H. pylori感染不是胃肠道症状的主要驱动因素.
- 虽然H. pylori不是SSc中胃肠道问题的主要原因,但根除疗法可以导致症状改善.
- 尿素呼吸检测是检测当前H. pylori感染的可靠方法.
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