由于与剂量相关的黄补充剂的次要原因,急性泛化脱血性 pustulosis
Hannah Riva1, Elena Skaribas2, Maleka Najmi3
1Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas, USA.
概括
一名妇女在增加黄补充剂剂量后出现了严重的皮疹. 这一案例表明黄可能导致急性泛性脱血性 pustulosis (AGEP),一个严重的皮肤反应.
科学领域:
- 皮肤病学 皮肤病学
- 毒理学 毒理学 毒理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 急性全身脱血性 pustulosis (AGEP) 是一种严重的皮肤药物不良反应.
- 虽然通常与抗生素有关,但各种药物甚至草药补充剂可以触发AGEP.
研究的目的:
- 报告一个可能由黄诱导的AGEP病例.
- 为了突出黄剂量与AGEP发展之间的关联.
- 强调在AGEP病因学中考虑草药补充剂的重要性.
主要方法:
- 一个55岁的女性患有快速进展的皮疹的案例介绍.
- 皮肤活检的临床和组织病理学检查.
- 对患者病史的审查,包括最近增加的黄补充剂摄入量.
主要成果:
- 患者呈现出与AGEP相一致的扩散和带有的红血斑块,与AGEP相一致.
- 组织病理学揭示了海绵性皮肤炎和带有埃索诺菲尔的角膜下疹.
- 这是第二个报告的黄诱导的AGEP病例,也是第一个表明剂量反应关系的病例.
结论:
- 黄,特别是在增加剂量的情况下,可能会触发AGEP.
- 包括补充剂使用在内的全面的患者病史对于诊断和管理AGEP至关重要.
- 对于临床医生来说,意识到草药补充剂诱导的不良药物反应至关重要.
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