相关实验视频

Updated: Apr 30, 2026

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Published on: August 8, 2022

多级工程人工紧骨通过双向冷驱动的矿化原蛋白微纤维的层状组织

Lingwenyao Kong¹, Yonggang Zhao², Yang Xiong³

¹State Key Laboratory of New Ceramics and Fine Processing, Key Laboratory of Advanced Materials of Ministry of Education, School of Materials Science and Engineering, Tsinghua University, Beijing, 100084, China.

Bioactive materials

|June 24, 2024

概括

研究人员开发了模仿自然骨的人工紧骨 (ACB).

科学领域:

生物材料工程生物材料工程
材料科学材料科学材料科学
生物矿物化生物矿物化

背景情况:

自然骨的复杂结构和机械性能激发了合成材料的发展.
在人工材料中复制骨的特征存在重大挑战.

研究的目的:

为了制造一个宏观的人工紧骨 (ACB) 材料.
为了达到与天然骨的结构和机械相似性.

主要方法:

使用连续的连续制造工艺.
采用生物仿真矿化原,双向冷造和压力驱动的融合.

主要成果:

成功制造出具有矿物化原体微纤维的状对齐的ACB材料.
ACB具有高矿物质含量 (70.9%) 和密度 (2.2 g/cm3),与自然皮层骨相比较.
实现了与天然骨相似的特殊机械性能 (刚性,硬度,屈曲强度).

结论:

制造的ACB密切复制自然骨的组成,结构和机械特性.
ACB表现出优异的湿式机械性能,生物相容性和体内骨质生成潜力.
ACB适用于骨科,牙科和面外科的各种生物医学应用.

关键词:

人工紧的骨头的人工紧骨头双向的冷造方式层次结构结构的层次结构.矿物化原蛋白微纤维细胞.

更多相关视频

Microengineering 3D Collagen Hydrogels with Long-Range Fiber Alignment

Microengineering 3D Collagen Hydrogels with Long-Range Fiber Alignment

Published on: September 7, 2022

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

Published on: July 14, 2023

相关概念视频

Bacterial Protein Maturation

Bacterial Protein Maturation

Bacterial protein maturation is a tightly regulated process that ensures newly synthesized polypeptides achieve correct functional conformations. This maturation involves a series of modifications, folding events, and quality control steps, often assisted by specialized chaperone proteins.N-Terminal ModificationsThe maturation of bacterial polypeptides begins cotranslationally as the polypeptide exits the ribosome. The first amino acid, N-formylmethionine (fMet), is typically modified at the...