相关实验视频
Updated: Jun 23, 2025

13:13
Biochemical Measurement of Neonatal Hypoxia
Published on: August 24, 2011
14.1K
患有低血糖症的新生儿中过渡性新生儿皮质过低症 - - 共存还是原因?
Sunetra Mondal1, Lakshmi Nagendra2, Amarta S Chowdhury3
1Department of Endocrinology, Healthworld Hospitals, Durgapur, India.
Indian journal of endocrinology and metabolism
|June 24, 2024
概括
风险婴儿的新生儿低血糖可能与短暂的低皮质醇症有关. 在大多数情况下,用皮治疗可缓解低血糖症,皮质醇水平在几个月内恢复正常.
科学领域:
- 新生儿科学 新生儿科学
- 内分泌学 在内分泌学.
- 儿科研究 儿科研究
背景情况:
- 过早出生,出生体重低 (LBW) 或经历围产压力的婴儿面临新生儿低血糖症的高风险.
- 在这种脆弱的新生儿群体中观察到过渡性低皮质醇 (低皮质醇水平).
研究的目的:
- 描述患有持续低血糖症和过渡性低皮质醇症的新生儿的临床生物化学参数.
- 调查低皮质醇在新生儿低血糖症中的作用和皮治疗的疗效.
主要方法:
- 一项对5名患有持续低血糖和低皮质醇水平的新生儿进行描述性研究.
- 在关键样本测试期间分析血糖,胰岛素,皮质醇,GH和ACTH水平.
- 临床评估,成像 (USG大脑和上腺) 和电解质监测.
主要成果:
- 所有五个新生儿的出生体重都很低,其中四个早产. 四名患有围产期窒息症,两名患有新生儿败血症.
- 三名婴儿表现出高胰岛素症,而两名婴儿在低血糖期间具有无法检测的胰岛素水平.
- 皮质醇的中位数为1.9mcg/dl;四名婴儿对口服皮质醇反应良好,降低了血糖水平. 皮质醇的中位恢复时间为4个月.
结论:
- 过渡性低皮质醇症可能会导致高危新生儿的低血糖症,即使胰岛素水平不同.
- 治疗性葡萄糖皮质激素在新生儿的作用,在低血糖期间有记录的低皮质醇症,需要进一步的研究.
- 密切跟踪至关重要,以监测这些婴儿的皮质醇水平自发恢复.
相关概念视频
Hypoglycemia and Glucagon
256
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
256
Pathophysiology of Diabetes
919
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
919
Glucose Transporters
22.6K
Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
22.6K
Overview of Carbohydrate Metabolism
902
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
902
Diabetes Mellitus: Type 2 and Gestational
2.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.3K
Glucose Homeostasis: Regulation of Blood Glucose
1.6K
Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
1.6K

