印度1型糖尿病儿童和青少年的动态肌肉功能参数:一种病例对照研究
Sonal V Kasture1,2, Shruti A Mondkar1, Anuradha V Khadilkar1,2
1Department of Growth and Paediatric Endocrinology, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, 32, Sassoon Road, Pune, Maharashtra, India.
Indian journal of endocrinology and metabolism
|June 24, 2024
概括
患有1型糖尿病 (T1DM) 的儿童和青少年表现出肌肉功能受损 (MF). 低血糖控制,以HbA1c为指标,与减少MF有关,可能导致成人肉症.
科学领域:
- 儿科 儿科 儿科
- 内分泌学 在内分泌学.
- 运动医学 运动医学
背景情况:
- 1型糖尿病 (T1DM) 越来越多地被认为会影响青少年的肌肉功能 (MF).
- 关于印度儿童和青少年T1DM动态MF的数据有限,这阻碍了对身体健康影响的充分理解.
研究的目的:
- 使用跳跃机制 (JM) 评估T1DM的印度儿童和青少年的动态肌肉功能 (MF),与使用跳跃机制 (JM) 的健康对照相比.
- 确定诊断为T1DM的儿童和青少年中MF的预测因子.
主要方法:
- 这是一项涉及266名参与者 (133名T1DM患者,133名对照患者) 的横截面观察研究,年龄在6-19岁之间.
- 用跳跃机理学 (JM) 评估肌肉功能,测量最大相对功率 (Pmax/质量) 和最大相对力 (Fmax/BW).
- 统计分析包括独立的样本t测试和线性回归,记录了人体测量,身体成分和HbA1c水平.
主要成果:
- 与健康对照组相比,患有T1DM的儿童和青少年的Pmax/质量和Fmax/BW显著降低 (P<0.05).
- 身体质量指数和肌肉质量指数 (LMI) 与MF参数之间发现了积极的关联.
- 在T1DM组中观察到胰岛素需求和HbA1c与Fmax/BW之间的负相关性. HbA1c和LMI被确定为MF的显著预测因素.
结论:
- 1型糖尿病 (T1DM) 与儿童和青少年的肌肉功能受损有关.
- 低血糖控制 (较高的HbA1c) 是降低MF的重要危险因素,独立于糖尿病持续时间.
- 这些发现表明,如果不能有效地管理,可能会导致成年后的肉症.
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