从70岁及以上的DBD捐赠者进行移植后的长期结果
Jørn Petter Lindahl1, Anders Åsberg1,2, Kristian Heldal1,3
1Department of Transplant Medicine, Section of Nephrology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Transplantation direct
|June 24, 2024
概括
来自70岁以上的捐赠者的移植显示了可接受的长期患者和移植存活率,尽管与年轻的捐赠者相比风险增加. 鉴于器官短缺,这一发现令人鼓舞.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 移植手术 移植手术
- 老年医学 老年医学
背景情况:
- 越来越多的器官短缺导致使用来自老年已故脑死亡 (DBD) 捐赠者的脏.
- 评估70岁及以上的DBD捐赠者移植的长期结果至关重要.
研究的目的:
- 评估70岁及以上DBD捐赠者的移植对患者和移植的生存的长期影响.
- 将结果与年轻的DBD捐赠者的脏进行比较.
主要方法:
- 从DBD捐赠者 (2007-2022) 来进行的1417次初次移植病例的回顾性分析.
- 捐赠者分为三个年龄组:70岁以上,60-69岁和45-54岁 (参考).
- 卡普兰-梅尔图和多变量考克斯回归用于分析患者和移植存活率.
主要成果:
- 与45-54岁组相比,70岁以上的捐赠者显示患者死亡 (1.62) 和移植损失 (1.94) 的调整后危险比较高.
- 与60-69岁年龄组相比,70岁以上的捐赠者对患者死亡的调整风险比为1.12和移植损失的调整风险比为1.23.
- 随访时间中位数为9.3年.
结论:
- 使用70岁及以上的DBD捐赠者的移植产生了可接受的长期结果.
- 这种方法对于解决移植器官短缺问题是令人鼓舞的.
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