肺功能下降与中风风险之间的关联:从观察性研究和门德尔随机化研究的见解
Jiadong Wang1,2, Junjie Lin3, Yujie Zheng1
1Hangzhou Third People's Hospital, Hangzhou, China.
Frontiers in neurology
|June 24, 2024
概括
肺功能下降,以下峰呼气流 (PEF) 表示,与中风风险增加有关. 监测PEF可能有助于全球初级中风预防策略.
科学领域:
- 肺部医学 肺部医学
- 神经学 神经学
- 流行病学 流行病学
背景情况:
- 卒中是全球死亡和残疾的主要原因,不成比例地影响低收入和中等收入国家.
- 肺功能下降是已确定的中风风险因素,但对这一关联的研究,特别是使用大量人口样本,仍然有限.
- 这项研究调查了肺功能与中风发病率之间的关系.
研究的目的:
- 为了探索肺功能,特别是峰值呼气流 (PEF) 和中风的发生率之间的联系.
- 评估PEF和中风风险之间的横截面和纵向关系.
- 使用遗传数据调查PEF和中风之间的潜在因果关系.
主要方法:
- 来自美国国家横截面研究 (n=13,371) 和中国国家队列研究 (n=11,192) 的数据分析.
- 应用多变量逻辑回归和考克斯比例危险回归来评估关联.
- 利用来自欧洲人口的公开可用的GWAS数据进行孟德尔的随机化分析,以探索因果关系.
主要成果:
- 横截面分析表明PEF降低和中风风险增加之间存在关联.
- 纵向分析显示,与最低的相比,在较高的PEF第三级组中,中风发病率的风险降低了19-21.4%.
- 门德尔随机化分析显示,较高的PEF水平与中风风险降低有显著关联.
结论:
- 通过PEF测量肺功能下降是中风的重要危险因素.
- 峰值呼气流作为监测肺功能的一个简单,准确的指标.
- 在社区和患者环境中,PEF监测可以成为预防中风的重要工具.
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