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在使用磁共振成像 (MRI) 进行肝转移的瘤划分的观察者间变化

Julia E Peltenburg¹, Ali Hosni², Rana Bahij³

¹Department of Radiation Oncology, The Netherlands Cancer Institute, Postal Address: Plesmanlaan 121, 1066CX Amsterdam, The Netherlands.

Physics and imaging in radiation oncology

|June 24, 2024

概括

对于肝转移的磁共振成像 (MRI) 引导立体性身体放射疗法 (SBRT) 的观察者间变异在1.3-1.6毫米之间. 瘤的规律性与这种变化有显著的相关性,使得患者特异性规划目标体积 (PTV) 边缘成为可能.

科学领域:

辐射瘤学辐射瘤学
医疗成像医学成像
在瘤学瘤学.

背景情况:

磁共振成像 (MRI) 引导的立体电动身体放射疗法 (SBRT) 是一种新兴的高精度,非侵入性治疗肝转移的方法.
瘤划分的观察者间变化 (IOV) 对准确的规划目标体积 (PTV) 边缘构成了挑战.

研究的目的:

在基于MRI的肝转移总瘤体积 (GTV) 划分中量化IOV.
确定影响IOV的患者特定因素.

主要方法:

八名放射瘤学家从22名肝转移 (结肠直肠,乳腺,肺) 患者的MRI扫描中划出了GTV.
使用距离的标准偏差量化IOV; 进行了具有和没有异常值的分析.
评估了IOV与瘤起源,体积和规律性之间的相关性.

主要成果:

平均IOV为1.6毫米 (包括异常值) 和1.3毫米 (不包括异常值).
在IOV和瘤起源或体积之间没有发现显著的相关性.
在IOV和瘤规律性之间观察到显著的负相关性 (斯皮尔曼的 ρs = -0.66; p = 0.002).

结论:

基于MRI的IOV用于肝转移GTV划分范围在1.3-1.6毫米之间,为PTV边际计算提供信息.
瘤规律性是影响IOV的重要因素,这表明患者特异性边际调整的潜力.

关键词:

在GTV上,GTV就是GTV.观察者之间的变化 (IOV)肝脏转移的发生.这就是为什么MRI是MRI.质量保证 (QA) 是一种质量保证.瘤的划界是指瘤的划界

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