相关实验视频

Updated: Jun 23, 2025

Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve

Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve

Published on: June 14, 2017

血清蛋白质学研究心脏置换手术后的认知障碍:一个前性观察性研究

Huanhuan Ma^1,2, Yiyong Wei³, Wei Chen⁴

¹Department of Anesthesiology, Medical College of Soochow University, Soochow, Jiangsu Province, China.

|June 24, 2024

概括

术后神经认知障碍 (PND) 影响心脏手术后16.8%的患者. 这项研究确定了与PND发展相关的关键风险因素和特定蛋白质,如GSTO1,IDH1,CAT和PFN1.

科学领域:

心脏病学心脏病学
神经学神经学
蛋白质组学是指蛋白质组学.

背景情况:

在心脏手术后,外科手术期间的神经认知障碍 (PND) 是一个重大问题.
驱动PND的确切机制在很大程度上是未知的.
心脏门置换手术具有PND发展的高风险.

研究的目的:

在心脏门置换后发展PND的患者中调查血清蛋白质组学差异.
确定与PND相关的潜在生物标志物和风险因素.
探索PND和氧化应激蛋白之间的关系.

主要方法:

一项前性观察性研究,涉及226名接受心脏门手术的患者.
根据得分,患者被分为非PND和PND组.
倾向分数匹配 (PSM) 用于为蛋白质组分析创建可比的组.
血清蛋白质组学用于识别差异表达蛋白质.

主要成果:

手术后六周内PND的发生率为16.8%.
已确定PND的风险因素包括年龄,慢性疾病,sufentanil剂量和心肺旁路术 (CPB) 持续时间.
蛋白质组分析显示了31种下调调节的蛋白质和6种上调调节的蛋白质.
GSTO1,IDH1,CAT和PFN1与PND有显著的关联.

结论:

PND的发生可能与氧化压力相关蛋白质的变化有关.
这项研究为未来对PND的调查提供了有价值的蛋白质组数据.
这些发现有助于理解PND在全身麻醉和外科手术的背景下.

关键词:

心脏门的替换术.手术后的神经认知障碍 (PND)倾向性得分匹配 (PSM) 是一种方法.蛋白质组是蛋白质组的组成部分.血清的血清是什么意思

更多相关视频

A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status

A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status

Published on: October 20, 2016

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Published on: February 14, 2017

相关概念视频

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...