药剂师管理的基尿素处方协议改善了状细胞病患者的摄入量和优化
Cameron Roessner1,2, Trudy Sale1, Kelsey Uminski1,3
1Southern Alberta Rare Blood and Bleeding Disorders Comprehensive Care Program, Foothills Medical Center, Calgary, AB, Canada.
Advances in hematology
|June 24, 2024
概括
一个由药剂师领导的协议显著提高了状尿素在状细胞病 (SCD) 患者的使用. 这种方法几乎使治疗次数翻了一番,并优化了剂量以获得更好的患者结果.
科学领域:
- 血液学 血液学 血液学
- 药理学 药理学是指药理学的学科.
- 临床药房 临床药房
背景情况:
- 状细胞疾病 (SCD) 是一种普遍存在的遗传疾病,具有严重的并发症.
- 氧尿素是SCD的有效治疗方法,但其采用率很低.
- 在SCD管理中,基尿素吸收和最佳剂量的障碍仍然存在.
研究的目的:
- 评估一个由药剂师领导的协议,以提高基氨酸的摄取量和优化SCD患者的剂量.
- 评估标准化处方,监测和患者咨询对治疗坚持的影响.
- 为了确定药剂师干预的有效性,以达到氧尿素的最大耐受剂量 (MTD).
主要方法:
- 在2020年1月至2023年9月的综合护理计划中进行了一项试点研究.
- 实施药剂师主导的氧尿素处方,监测和剂量定位的协议.
- 对患者数据的回顾性分析,对氧尿素的启动,MTD的实现,以及血红蛋白F水平.
主要成果:
- 在符合条件的SCD患者中,尿素的摄入量从37.8%增加到62.5%.
- 在MTD的患者比例从35.1%上升到63.8%,平均需要10个月才能达到MTD.
- 平均血红蛋白F水平从13.9%增加到19.7%.
结论:
- 一个由药剂师领导的协议有效地增加了SCD患者的基尿素摄入量和MTD成就.
- 该模型展示了一种成功的策略,用于优化SCD治疗在专门的诊所环境.
- 药剂师的参与对于改善治疗状细胞疾病的治疗目标和治疗目标至关重要.
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