制造基于CMC/PVA/Dextrin的聚合物膜,用于控制释放具有增强抗菌活性的Cefixime
Arif Nazir1, Mazhar Abbas2, Dure Najaf Iqbal1
1Department of Chemistry, The University of Lahore, Lahore, Pakistan.
概括
这项研究开发了一种新型的碳素甲基纤维素,聚乙烯醇和德克斯特林水凝膜,用于持续的Cefixime抗生素输送. 聚合物矩阵展示了受控的药物释放和对常见病原体有前途的抗菌活性.
科学领域:
- 材料科学 材料科学 材料科学
- 聚合物化学 聚合物化学
- 制药科学 制药科学
背景情况:
- 聚合物在先进的药物输送系统中起着至关重要的作用.
- 开发用于持续释放抗生素的有效矩阵对于对抗传染病至关重要.
研究的目的:
- 研究一种新型的碳素甲基纤维素 (CMC),聚乙醇 (PVA) 和基于德克斯特林的水凝膜对持续药物输送的潜力.
- 为了评估cefixime输送的准备的水凝膜的物理化学特性和抗菌疗效.
主要方法:
- 水凝膜是使用溶剂造方法制造的,其中CMC,PVA和右的比例各不相同.
- 描述涉及富里埃变换红外光谱 (FTIR),扫描电子显微镜 (SEM),紫外线可见光谱,热重力测量分析 (TGA) 和胀研究.
- 评估了Cefixime药物释放动力学和针对特定细菌菌株的抗菌活性.
主要成果:
- 该CMC/PVA/dextrin水凝膜表现出理想的膨胀能力和热稳定性.
- 在酸盐缓冲盐水 (PBS) 中观察到120分钟内持续释放cefixime.
- 准备好的膜显示出有前途的抗菌活性,可以对抗Proteus vulgaris,沙门氏菌,大肠杆菌和细菌细菌.
结论:
- 开发的CMC/PVA/dextrin水凝膜是一种无毒和热稳定的材料,适合控制的cefixime药物输送.
- 这种基于聚合物的系统有可能通过持续的抗生素释放来有效治疗传染病.
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