在接受皮肤冠状动脉干预的患者中,手腕关节脉冲波速的长期预后影响
Byung Sik Kim1, Jong-Hwa Ahn2, Jeong-Hun Shin1
1Division of Cardiology, Department of Internal Medicine, Hanyang University College of Medicine, Hanyang University Guri Hospital, Guri-si, Republic of Korea.
Frontiers in medicine
|June 24, 2024
概括
穿皮冠状动脉干预 (PCI) 后患者的臂脉冲波速率 (baPWV) 升高预测了长期不良临床事件,包括缺血和出血风险. 这种标志物有助于识别高风险个体,以便更好地管理.
科学领域:
- 心血管医学 心血管医学
- 血管生物学 血管生物学
- 临床心脏病学 临床心脏病学
背景情况:
- 高风险患者群体中动脉硬的长期临床影响尚未完全理解.
- 腕脉冲波速度 (baPWV) 是动脉硬性的非侵入性测量.
研究的目的:
- 评估baPWV在经过皮肤冠状动脉干预 (PCI) 的患者的预后影响.
- 为了确定baPWV是否可以识别PCI后临床不良事件风险较高的患者.
主要方法:
- 分析了3930名接受PCI的患者的现实世界注册表.
- 在出院前使用baPWV测量了动脉硬度.
- 患者被分为高和低baPWV组 (切断值1891厘米/秒).
- 主要结局是净不良临床事件 (NACE);次要结局包括主要不良心脏和脑血管事件 (MACCE) 和4年的主要出血.
主要成果:
- 较高的baPWV与PCI后4年临床事件的增加有线相关.
- 高baPWV组显示NACE,MACCE和重大出血的累积发病率更高.
- 多变量分析显示,高的baPWV显著增加了NACE (aHR1.44),MACCE (aHR1.40) 和大出血 (aHR1.94) 的风险.
结论:
- 腕脉冲波速度是PCI治疗患者长期临床结果的重要独立预测指标.
- baPWV有效地识别高风险表型,包括缺血和出血事件.
- 这些发现强调了baPWV在PCI后患者风险分层方面的临床实用性.
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