针对Helicobacter pylori的新型治疗方案:一个更新的系统审查
Ting-Ting Huang1, Yong-Xiao Cao1, Lei Cao2
1Department of Pharmacology, School of Basic Medical Science, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
Frontiers in microbiology
|June 24, 2024
概括
Helicobacter pylori (H. pylori) 根除面临挑战,原因是抗菌耐药性不断上升. 新的策略,包括改变氧气水平和探索疫苗,显示未来H. pylori治疗的希望.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
背景情况:
- 杆菌 (H. pylori) 感染是一种普遍的慢性细菌感染.
- 根除H. pylori对于预防胃病如和癌症至关重要.
- 目前的三倍和四倍疗法由于抗菌耐药性而越来越无效.
研究的目的:
- 审查有关H. pylori感染和抗菌耐药性的最新信息.
- 探索当前和新兴的H. pylori根除治疗选择.
- 确定有效根除H. pylori的新策略.
主要方法:
- 在PubMed上进行系统的文献搜索,搜索到2024年3月之前发表的文章.
- 使用的关键词:"H. pylori"",H. pylori感染"",H. pylori疾病"",H. pylori消灭"",H. pylori抗菌耐药性".
- 分析新兴的根除疗法和新的方法.
主要成果:
- 尽管使用抗微生物药物,但每年的H. pylori根除率继续下降.
- 新兴疗法如诺普拉桑,益生菌辅助疗法和H. pylori疫苗显示出潜力,但需要进一步评估.
- 改变胃环境中的氧气度是一种有希望的新根除策略.
结论:
- 现有的H. pylori根除方法受到抗菌耐药性增加的挑战.
- 新的治疗策略,包括vonoprazan,益生菌,疫苗和氧气修饰正在开发中.
- 需要进一步的研究来验证这些新兴的H. pylori根除方法的有效性.
相关概念视频
01:16Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
358
Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
358
01:26Peptic Ulcer Disease IV: Management
87
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
87
01:28Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
109
Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
109
01:28Acid Suppressive Drugs for Peptic Ulcer Disease: Histamine H2-Receptor Antagonists
423
Histamine H2 receptors, which are intricately located on the basolateral membrane of parietal cells, play a crucial role in modulating gastric acid secretion. When released from enterochromaffin-like cells, histamine engages H2 receptors, initiating the cyclic AMP (cAMP) pathway. In this pathway, adenylyl cyclase converts ATP into cAMP, elevating intracellular cAMP levels. The activation of protein kinase A follows, stimulating the proton pump. This stimulation prompts the secretion of hydrogen...
423
01:23Gastritis III: Clinical Manifestations and Management
214
The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
214
01:13Acid Suppressive Drugs for Peptic Ulcer Disease: Proton Pump Inhibitors
374
Peptic ulcers, often induced by H. pylori infections or NSAID usage, arise from disruptions in the delicate balance of gastric acid production. Peptic ulcers stem from heightened gastric acid levels due to H. pylori infections or NSAID use. The protective mucus layer diminishes in the presence of these factors, allowing gastric acid to erode the stomach lining and form ulcers.
Gastric acid, a potent cocktail of hydrogen and chloride ions, is produced in specialized parietal cells within the...
Gastric acid, a potent cocktail of hydrogen and chloride ions, is produced in specialized parietal cells within the...
374