作为急性胰腺炎的严重性和预后标记物的D-二聚物
1Department of General Surgery, St. John's Medical College Hospital, Bengaluru, Karnataka, India.
概括
一个单一的D-二次测试可以预测复杂的急性胰腺炎 (CAP) 和其严重程度. 升高的D-二聚物水平与疾病进展,器官衰竭和重症监护室 (ICU) 需求相关.
科学领域:
- 生物化学 生物化学
- 医学诊断 医学诊断 医学诊断
- 临床医学 临床医学
背景情况:
- 目前的急性胰腺炎 (AP) 评分系统缺乏对并发症的早期预测价值.
- 预测复杂的急性胰腺炎 (CAP),包括严重的AP,局部问题和ICU入院,需要一个单一的,有效的早期测试.
研究的目的:
- 评估D-二次体作为预测CAP及其严重程度的单一诊断标记.
- 为了将D-二元水平与AP患者的确定的严重性得分和临床结果相关联.
主要方法:
- 研究了30名AP患者,在发病后3天内测量D-二聚合物和C-反应蛋白.
- 评估APACHE II,兰森得分和CT严重性指数;监测器官衰竭和ICU需求.
主要成果:
- 在CAP (2732 ng/L),CT异常发现 (1916 ng/L) 和器官衰竭 (4776 ng/L) 中,D-二聚合物水平显著更高.
- D-二次数与疾病严重程度 (P=0.04),ICU入院 (P=0.021) 和APACHE II评分 (P=0.01) 相对相关.
- D-二次元值预测了CAP (>933.5 ng/L),局部并发症 (>827.5 ng/L) 和器官衰竭 (>1060.5 ng/L).
结论:
- D-dimer有效地预测了复杂的急性胰腺炎及其结果.
- 早期的D-二次体测量可以指导临床决策和患者转诊,特别是在资源有限的环境中.
- D-二次体反映了AP中的早期致病过程,如凝血病和微血栓.
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