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优化下静脉膜过器设计:对支架配置进行计算流体动力学研究,以提高血液动力学性能和减少血栓形成

Byeong-Jun Kim¹, Chiseung Lee^2,3

¹Department of Biomedical Engineering, Graduate School, Pusan National University, Busan 49241, Republic of Korea.

|June 24, 2024

概括

优化下静脉膜过器设计,采用16个支架,长度为20毫米,倾斜角度为0°,可最大限度地减少血栓形成和血液动力学问题. 这种配置提高了过器在预防深静脉血栓和肺栓塞方面的有效性.

科学领域:

生物医学工程生物医学工程
心血管研究研究心血管研究
医疗器械设计医疗器械设计

背景情况:

下腔静脉 (IVC) 过器可以预防深静脉血栓塞 (DVT) 和肺栓塞 (PE),降低死亡率.
尽管取得了进展,IVC过并发症如过血栓症和复发性PE仍然存在.
过器的几何结构显著影响血栓形成,捕获,溶解和血液动力学.

研究的目的:

分析IVC波器几何参数变化对血液动力学和血栓行为的影响.
确定最佳的过器设计,以平衡血栓管理并最大限度地减少不良影响.
为了研究墙壁剪切应力与IVC过器内血栓形成/溶解之间的关系.

主要方法:

使用卡罗模型进行计算流体动力学 (CFD) 模拟.
对不同过器设计的分析:支架的数量,支架臂的长度和倾斜角度.
血液动力学参数的评估:流速,压力,循环,停滞区和壁切应力.

主要成果:

再循环和停滞区是受到过器几何形状影响的关键因素.
在没有血小板激活的情况下进行血栓溶解的最佳壁切应力范围在0至4Pa之间.
过器内压力度最小化可以降低血小板激活和血栓过的风险.

结论:

过器设计有16个支臂支架,长度为20毫米,倾斜角度为0°,提供最好的平衡.
这种配置最大限度地减少了血液动力学障碍,如停滞和循环回流区.
通过这种优化的设计,维持了足够的壁切应力以有效地溶解血栓.

关键词:

血液凝块治疗血液凝块治疗计算流体动力学的流体动力学.计算机建模和仿真过器优化过器优化在形医学中.下腔静脉的过器是下腔静脉的过器.

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