在瘤学AURKA的知识映射:一个先进的圣经识别分析 (1998-2023)
Qiong Zhou1, Chunyu Tao1, Jiakai Yuan1
1Department of Medical Oncology, Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu Province 210093, PR China.
Heliyon
|June 24, 2024
概括
这份图书统计分析探讨了AURKA在癌症中的研究,揭示了它的演变,趋势和预后价值. 这些发现指导了未来的瘤学研究和这种关键癌症分子的临床应用.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 生物信息学是一种生物信息学.
背景情况:
- 极光激酶A (AURKA) 是细胞分裂的关键调节剂,也是癌症发展的重要因素.
- 失调的AURKA活性促进瘤生长,基因组不稳定性,以及对癌症疗法的抗性.
- 了解AURKA的作用对于推进癌症研究和治疗策略至关重要.
研究的目的:
- 对癌症中AURKA的全球研究进行全面的文献分析.
- 将AURKA瘤学研究的时间发展,研究趋势和新兴前沿映射出来.
- 研究AURKA信号通路,蛋白相互作用及其在癌症患者生存中的预后意义.
主要方法:
- 网络科学数据库 (1998-2023) 的图书统计分析.
- 使用VOSviewer,Citespace,Biblioshiny R和Cytoscape进行数据挖掘和可视化.
- 包括一个关于AURKA在癌症中的预后价值的元分析.
主要成果:
- AURKA癌症研究的演变和趋势的详细地图.
- 确定涉及AURKA的关键信号通路和蛋白质相互作用网络.
- 量化了AURKA对各种癌症患者存活率的预后影响.
结论:
- 本研究提供了AURKA在瘤学研究的全面概述,强调了其动态演变和影响.
- 这些发现为AURKA的分子机制和临床相关性提供了宝贵的见解.
- 这项工作作为未来研究方向和潜在的治疗策略的指南,针对癌症中的AURKA.
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