肌肉增生在克罗恩病狭窄症:通过厚薄的
Ido Veisman1, William J Massey1, Idan Goren1
1Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, United States.
American journal of physiology. Cell physiology
|June 24, 2024
概括
光滑肌肉细胞增生导致克罗恩病 (CD) 的狭窄. 针对这种肌肉加厚提供了一个新的治疗策略,用于纤维肌性并发症.
科学领域:
- 胃肠病学 胃肠病学
- 炎症性肠道疾病是什么
- 病理生理学 病理生理学
背景情况:
- 纤维化克罗恩病 (CD) 导致症状性胃肠狭窄.
- 炎症管理的进步并没有阻止纤维肌性进展,往往需要手术.
- 平滑肌肉细胞增生越来越被认为是狭窄的关键驱动因素.
研究的目的:
- 审查CD狭窄的光滑肌肉细胞增殖机制.
- 为了确定与肌肉加厚相关的潜在治疗点.
- 为了告知未来的研究和临床策略纤维肌性CD.
主要方法:
- 文献综述综合当前的证据.
- 对平滑肌肉细胞增生背后的机制的分析.
- 与其他器官系统中的类似过程进行比较.
主要成果:
- 光滑肌肉细胞增生显著导致CD的光线狭窄.
- 在CD中肌肉增殖的机制与其他纤维状况有相似之处.
- 肌肉加厚代表了一个新的治疗目标.
结论:
- 了解光滑肌肉细胞增生症对于管理纤维肌性CD至关重要.
- 准肌肉增殖可能会减轻狭窄的形成和进展.
- 这种方法可能有利于患有CD和其他纤维肌性疾病的患者.
相关概念视频
Esophageal Strictures-I: Introduction
81
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
81
Inflammatory Bowel Disease II: Crohn's Disease
213
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
213
Inflammatory Bowel Disease V: Surgical Management
139
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
139
Esophageal Strictures-II: Clinical Features and Management
61
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
61
Chronic Bowel Disorders: Introduction
440
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
440
Fascicle Arrangement in Skeletal Muscles
1.9K
Fascicles are bundles of muscle fibers in a skeletal muscle. Muscle fascicle arrangement is directly associated with the power and range of motion of various muscles. The configuration of these fascicles can vary, leading to different functional outcomes.
The four primary types of muscle based on fascicle arrangement are:
The four primary types of muscle based on fascicle arrangement are:
1.9K


