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作为mTOR通路激活的标志物和在真菌细菌感染中的治疗标,PDCD4

Ruchi Paroha¹, Jia Wang¹, Sunhee Lee¹

¹Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas, USA.

Microbiology spectrum

|June 24, 2024

概括

编程细胞死亡蛋白4 (PDCD4) 在真菌细菌感染中下调,表明哺乳动物的目标是拉巴胺素 (mTOR) 途径激活. 基于PDCD4的记者细胞识别了FDA批准的药物,可以抑制mTOR并阻碍菌根菌的生长.

科学领域:

免疫学免疫学免疫学
细胞生物学细胞生物学
传染性疾病传染性疾病

背景情况:

编程细胞死亡蛋白4 (PDCD4) 调节翻译,细胞亡和炎症.
PDCD4的表达与哺乳动物的拉巴胺素 (mTOR) 途径的标相反相关,拉巴胺素是细胞生长的关键调节者.
菌根菌感染对PDCD4和mTOR通路相互作用的影响需要进一步调查.

研究的目的:

为了研究在真菌细菌感染期间的PDCD4调制.
评估PDCD4作为这些感染中mTOR通路激活的生物标志物.
通过使用新型报告系统,识别潜在的mTOR抑制剂用于治疗菌根菌感染.

主要方法:

分析各种真菌菌菌感染中的PDCD4表达.
开发基于PDCD4的mTOR (Tor) 信号指示器 (TOSI) 报告器细胞.
执行针对mTOR通路的FDA批准药物的高通量选.

主要成果:

在各种真菌细菌感染中观察到PDCD4的持续下调.
基于PDCD4的TOSI记者细胞能够有效选mTOR抑制剂.
已识别的FDA批准的药物提高了PDCD4的调节,并抑制了巨细胞中的真菌细菌的增殖.

结论:

在真菌细菌感染中,PDCD4作为mTOR活性的显著生物标志物.
基于PDCD4的查是识别mTOR抑制剂的可行策略.
重新设计的针对mTOR的药物为新型宿主导治疗针对菌根菌病提供了潜在的潜力.

关键词:

经过FDA批准的药物库和药物查.在PDCD4中使用PDCD4.在mTOROR中使用mTOR.菌根细菌 (mycobacteria) 是一种细菌.

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