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Updated: Jun 23, 2025

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过度的STAU1凝聚剂驱动神经退行症中的mTOR翻译和自功能障碍

Ruiqian Zhao1, Shijing Huang1, Jingyu Li1

  • 1Department of Neurosurgery, Huashan Hospital, The Shanghai Key Laboratory of Medical Epigenetics, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Biomedical Sciences, School of Basic Medical Sciences, Fudan University, Shanghai, China.

The Journal of cell biology
|June 24, 2024
PubMed
概括

过多的Staufen1 (STAU1) 蛋白质会通过形成细胞质凝结物来引起神经退行性疾病,这些凝结物会促进mTOR翻译并损害自. 调节这些凝结物可能提供一种治疗策略.

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