对于子宫内膜癌的免疫治疗
Michiko Wada1, Wataru Yamagami2
1Department of Obstetrics and Gynecology, Keio University School of Medicine, 35 Shinanomachi, Shinjyuku-Ku, Tokyo, 160-8582, Japan. michikowada1216@gmail.com.
International journal of clinical oncology
|June 24, 2024
概括
免疫检查点抑制剂 (ICI) 在晚期子宫内膜癌 (EC) 中表现有前途. 布罗利祖马布与伦瓦提尼布结合改善了复发性EC的结果,无论微卫星不稳定 (MSI) 状态如何.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 免疫治疗是一种免疫疗法.
背景情况:
- 晚期复发性子宫内膜癌 (EC) 是一个重大的临床挑战,治疗选择有限.
- 基因组对EC分为四种亚型 (POLE,MSI-H,低拷贝数,高拷贝数) 的分类会影响预后和治疗策略.
- 子宫内膜癌表现出高的PD-1和PD-L1表达,特别是在MSI高的亚型中,这表明对免疫检查点抑制剂 (ICI) 的敏感性.
研究的目的:
- 审查ICI在治疗晚期复发性子宫内膜癌中的不断变化的作用.
- 突出佩布罗利祖马布单独或联合治疗EC的疗效.
- 讨论与ICI治疗相关的免疫相关不良事件 (irAEs) 的管理.
主要方法:
- 对复发性子宫内膜癌ICI治疗的临床试验数据和文献的审查.
- 基因组分类的分析及其与PD-L1表达和治疗反应的相关性.
- 评估涉及ICI,化疗和lenvatinib等向药物的组合疗法.
主要成果:
- 布罗利祖马布在高MSI复发性EC中表现出有效性.
- 与化学疗法相比,布罗利祖马布和伦瓦提尼布的联合治疗显著改善了整体存活率 (OS) 和无进展存活率 (PFS),无论MSI状态如何.
- 基于ICI的疗法越来越多地用于一线治疗,目前正在进行的试验将其与传统化疗进行比较.
结论:
- 强化治疗药物,特别是布罗利祖马布与伦瓦提尼布结合使用,在治疗晚期复发性子宫内膜癌方面取得了重大进展.
- 基于基因组分类,特别是MSI状态的治疗个性化是至关重要的.
- 虽然有效,但ICI可能会导致与免疫相关的不良事件 (irAEs),需要及时管理,特别是在组合疗法中.
更多相关视频
07:46Author Spotlight: Advancing Reproductive Immunology with a Protocol for the Quantitative Evaluation of Endometrial Immune Cells
Published on: October 13, 2023
1.2K
11:02Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
21.3K
相关概念视频
01:27Tumor Immunotherapy
511
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
511
02:57Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
01:30Cancer Vaccines
352
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
352
02:49Cancer Therapies
7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
02:38Mitogens and the Cell Cycle
6.5K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.5K