年龄对循环catecholamine变化的幅度的影响健康的循环马的改变
Katiuska Satué1, Esterina Fazio2, María Gemma Velasco-Martínez3
1Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, CEU-Cardenal Herrera University, Tirant lo Blanc, 7, Alfara del Patriarca, Valencia, 46115, Spain. ksatue@uchceu.es.
老年马显示神经递质水平发生变化. 年龄较大的母马具有较低的上腺素,多巴胺和血清激素,但较高的上腺素,表明神经系统活动的转变.
科学领域:
- 比较生理学比较生理学
- 神经内分泌学神经内分泌学
- 马类科学 马类科学
背景情况:
- 甲基醇胺 (CATs) 是重要的神经递质和激素.
- 在人类和动物中记录了与年龄相关的CAT变化.
- 这种与年龄相关的机制在马,特别是马中不太了解.
研究的目的:
- 为了研究随着年龄的增长在母马中甲基胺度的生理变化.
- 在不同年龄组的马匹中评估上腺素 (A),上腺素 (NA),多巴胺 (DA) 和血清激素 (5-HT) 的血水平.
主要方法:
- 采集了56只非怀孕的西班牙纯种马的血液样本,分为四个年龄组.
- 使用经过验证的竞争EIA (3-CAt EIA) 对马类样本进行A,NA,DA和5-HT的量化.
主要成果:
- 16岁以上的母马呈现较低的A,DA和5-HT,但与年轻群体相比,NA较高 (p <0.05).
- 13-16岁的母马的A值较低,NA值高于6-9岁和10-12岁的母马 (p < 0.05).
- 在A和NA (r=-0.72),NA和5-HT (r=-0.67) 之间发现了显著的负相关性;在A和5-HT (r=0.74) 之间存在正相关性.
结论:
- 大马的晚年与对交感神经系统占主导地位的转变有关.
- 衰老的母马表现出降低了血清激素活性.
- 这些发现突显了马体生理学中年龄相关的神经化学变化.
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