空气污染和癌风险:系统审查和元分析
Lina Dahman1,2, Victoria Gauthier3,4, Aurore Camier5
1Service de Santé Publique, Epidémiologie, Economie de la Santé et Prévention, CHU de Lille, Lille, France.
Journal of nephrology
|June 24, 2024
概括
长期暴露于空气污染,特别是颗粒物 (PM10) 和二氧化 (NO2),与癌的风险增加有关. 由于研究的局限性,需要进一步的研究.
科学领域:
- 环境健康 环境健康
- 流行病学 流行病学
- 在瘤学瘤学.
背景情况:
- 癌风险因素尚未得到充分了解.
- 长期暴露于空气污染是癌的一个被低估的风险因素.
研究的目的:
- 系统地审查和元分析空气污染物暴露与癌风险之间的关联.
主要方法:
- 在EMBASE,PubMed,Web of Science,Cochrane图书馆和CINAHL数据库上进行系统的文献搜索.
- 对9项符合条件的研究进行随机效应元分析 (总共包括19篇文章).
- 对污染物水平增加10μg/m3计算的危险比率;评估异质性和偏差.
主要成果:
- 在PM10的10μg/m3增加与29%的癌风险增加有关 (HR=1.29,95% CI [1.10; 1.51]).
- 二氧化物增加10μg/m3与癌风险增加10%有关 (HR=1.10,95% CI [1.03; 1.18]).
- 暴露于PM10还表明癌发病率和死亡率的风险增加.
结论:
- 研究结果表明,PM10和NO2暴露与癌风险之间存在潜在联系.
- 由于研究数量有限和方法偏差风险,应谨慎解释结果.
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