在使用M-FISH的霍奇金淋巴瘤患者中表征化疗/放射治疗诱导的基因组混乱

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Updated: Jun 23, 2025

Detection of Inter-chromosomal Stable Aberrations by Multiple Fluorescence In Situ Hybridization mFISH and Spectral Karyotyping SKY in Irradiated Mice
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Detection of Inter-chromosomal Stable Aberrations by Multiple Fluorescence In Situ Hybridization mFISH and Spectral Karyotyping SKY in Irradiated Mice

Published on: January 11, 2017

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Sandra Ramos1, Sara Frias2,3

  • 1Laboratorio de Citogenética, Instituto Nacional de Pediatría, Ciudad de México, Mexico.

Methods in molecular biology (Clifton, N.J.)
|June 24, 2024
PubMed
概括

霍奇金淋巴瘤 (HL) 治疗导致患者干细胞持续的基因组混乱,可能增加二次癌症风险. 这项研究详细使用M-FISH来分析HL幸存者的治疗诱导的染色体不稳定性.

关键词:
化疗 化疗是一种化学疗法.染色体复杂性是一种染色体复杂性.染色体异常是一种染色体异常.这是基因组混乱.基因毒性 基因毒性这就是M-FISH.辐射疗法 辐射疗法

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Fluorescence in situ hybridization, or FISH, was developed in the early 1980s and has quickly become one of the most widely used techniques in cytogenetics. Labeled probes are used to bind complementary DNA or RNA sequences on a chromosome or in a region within a cell. Earlier, the probes could only be obtained by cloning or reverse transcription of a DNA template. Currently, the probe oligonucleotides can be synthesized synthetically. Additionally, with the advancement of optical techniques,...
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