在内镜外科手术后的结果中的性别差异:系统性审查和元分析
M T Ryan1, K Patel2, J L Fischer3
1Department of Otolaryngology - Head and Neck Surgery, Walter Reed National Military Medical Center, Bethesda, ML, USA.
Rhinology
|June 24, 2024
概括
患有慢性鼻炎 (CRS) 的女性在内镜外科手术 (ESS) 后报告了更糟糕的结果,特别是在患者报告的结果测量 (PROM) 中,如SNOT-22得分. 需要进一步的研究来解决这些性别差异.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 外科手术的结果
- 性别不平等的性别差异
背景情况:
- 性别对慢性鼻炎 (CRS) 术后结果的影响还不清楚.
- 内镜外科手术 (ESS) 是一种常见的CRS治疗方法,但性别差异性结果需要调查.
研究的目的:
- 分析慢性鼻炎 (CRS) 患者内镜鼻手术 (ESS) 后的性别特异性结果.
- 为了确定在接受ESS的男性和女性CRS患者之间恢复和症状负担的潜在差异.
主要方法:
- 在PubMed/Ovid,Embase和Cochrane数据库中进行了系统的文献搜索.
- 评估的结果包括成像/内镜疾病负担,患者报告的结果指标 (PROM),如SNOT-22,修订率和嗅觉功能.
- 分析采用了Mantle-Haenszel方法与随机效应模型.
主要成果:
- 在分析的32项研究中,19项报告了术后结果的显著性别差异,其中14项偏爱男性.
- 使用PROM的9项研究表明,男性的结果更好,女性始终显示出更高的手术前和术后SNOT-22得分.
- 在成像或内镜的疾病负担中没有发现显著的性别差异;嗅觉结果是混合的.
结论:
- 与男性相比,患有CRS的女性在手术前和手术后的SNOT-22得分较差.
- 结果中的性别差异在依赖患者报告的结果措施 (PROMs) 时最为明显.
- 进一步调查至关重要,以了解这些基于性别的差异的原因,并制定缓解策略.
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