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Updated: Jun 23, 2025

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用于预测自发早产的阴道免疫蛋白组:一项追溯纵向研究

Zachary Shaffer1,2,3, Roberto Romero1,4,5, Adi L Tarca1,2,6,7

  • 1Pregnancy Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services (NICHD/NIH/DHHS), Bethesda, United States.

eLife
|June 24, 2024
PubMed
概括

预测自发早产 (sPTB) 是一个挑战. 分析阴道免疫蛋白组揭示了与sPTL和PPROM相关的炎症转移,为早期检测提供了潜在的生物标志物.

关键词:
计算生物学是计算生物学.伟大的产科综合征.人类 人类 人类 人类 人类 人类 人类免疫学 免疫学 免疫学医学 医学 医学 医学 医学产科 产科 产科 产科过早分娩 过早分娩是什么系统生物学 系统生物学阴道生态系统的阴道生态系统

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Development of Immunocompetence01:22

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The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
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