肠道微生物特征和食纤维摄入量预测了肠道微生物群对抗性粉补充剂的反应
Sri Lakshmi Sravani Devarakonda1, Dorothy K Superdock1, Jennifer Ren1
1Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA.
Gut microbes
|June 24, 2024
概括
食纤维摄入量和肠道微生物组合可以预测个体对抗性粉 (RS) 补充的反应,为改善代谢健康的个性化营养策略铺平了道路.
科学领域:
- 营养科学 营养科学
- 微生物组研究 微生物组研究
- 人体生理学 人体生理学
背景情况:
- 耐性粉 (RS) 提供代谢健康益处,但个体反应各不相同.
- 预测RS反应的预测因素是未知的,阻碍了个性化的营养.
- 了解这些预测因素可以优化食纤维的好处.
研究的目的:
- 确定肠道微生物群的预测因素和宿主对抗性粉 (RS) 补充剂的生理反应.
- 研究饮食纤维摄入量,唾液氨酶 (AMY1) 和肠道微生物组合的作用.
- 告知精准营养策略,最大限度地提高食纤维的益处.
主要方法:
- 与59名健康成年人进行的交叉研究,消费RS类型2,RS类型4和可消化粉.
- 收集的便和唾液样本,食品记录.
- 分析了16S rRNA基因测序,便短链脂肪酸 (SCFA),AMY1基因拷贝数和唾液氨酶活性 (SAA).
主要成果:
- 饮食纤维摄入量预测RS消费后的微生物社区转移 (ASVs).
- 唾液氨酶指标不是RS反应的显著预测指标.
- 肠道微生物组组成和基线纤维摄入量预测了RS补充后的SCFA变化.
结论:
- 食纤维摄入量和基线肠道微生物组合是RS反应的关键预测因素.
- 评估这些因素可以指导个性化的RS建议.
- 使用这些见解的精准营养方法可以增强食纤维的好处.
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