在宫癌之后,随后出现一次性肺癌的风险:基于864,627例病例的定量分析
Sheng Gong1, Gang Li1, Dan Li1
1Department of Thoracic Surgery, The Public Health Clinical Center of Chengdu, Chengdu, P.R. China.
PloS one
|June 24, 2024
概括
与普通人群相比,宫癌幸存者患肺癌的风险要高得多. 这种增加的风险在各种患者人口统计和癌症特征中持续存在.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 癌症研究 癌症研究
背景情况:
- 宫癌是全球重要的健康问题.
- 了解幸存者的二次癌症风险对于长期健康管理至关重要.
研究的目的:
- 调查子宫癌患者随后发展为原发性肺癌的风险.
- 将这种风险与一般人群中观察到的发病率进行比较.
主要方法:
- 22项回顾性研究的系统综述和元分析.
- 包括864,627名参与者.
- 计算标准化发生率 (SIR) 和95%信心区间 (CI).
主要成果:
- 宫癌患者患肺癌的风险增加了2.63倍 (SIR=2.63,95% CI:2.37-2.91).
- 肺癌风险增加在包括随访持续时间,患者年龄和癌症恶性程度在内的亚组分析中是一致的.
- 统计学显著性得到证实,P < 0.001.
结论:
- 宫癌患者患二次肺癌的可能性要大得多.
- 这种增加的风险独立于年龄,随访期或恶性瘤的程度.
- 建议进一步进行高质量的前性研究,以验证这些发现.
相关概念视频
Cancer Prevention
6.1K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.1K
Relative Risk
150
Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
150
Skin Cancer
4.1K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.1K
Cancers Originate from Somatic Mutations in a Single Cell
11.9K
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
11.9K


