德克萨米他 - 普雷迪尼松组合治疗治疗状态喘疗程的结果
Shelby Nelipovich1, Sarah H Vepraskas2, Paula Soung2
1Department of Pediatrics, University of Rochester, Golisano Children's Hospital, Rochester, NY, USA.
概括
对于儿科喘,用德克萨梅他松和普雷迪尼松联合治疗的30天再入院率与单独使用普雷迪尼松相比相当. 德克萨米他单疗也给住院患者带来了类似的结果.
科学领域:
- 儿科肺病学 儿科肺病学
- 紧急医疗 紧急医疗
- 药理学 药理学是指药理学的学科.
背景情况:
- 德克萨米他是紧急病房中儿童喘状态的标准.
- 住院患者的决定涉及继续使用德甲或切换到普得尼松.
- 德甲,普得尼松和组合疗法的比较有效性尚不清楚.
研究的目的:
- 为了比较患者的特征和德克萨米他松,普雷迪尼松和结合疗法的结果,用于住院喘管理.
- 分析基于类固醇治疗方案的急诊室 (ED) 再利用率和医院再入院率.
主要方法:
- 对1697名住院患有喘相关诊断的儿童 (2-18岁) 的回顾性研究.
- 类固醇组:德克萨米他,普得尼松或组合疗法.
- 统计分析包括费舍尔的精确,奇平方,克鲁斯卡尔-瓦利斯和多变量后勤回归.
主要成果:
- 组合疗法 (58.0%) 是最常见的,其次是普得尼松 (35.2%) 和甲 (6.8%).
- 组合治疗患者的恶化严重程度低于普得尼松,但高于德克萨梅他松.
- 与普德尼松相比,甲和组合疗法与30天的ED再利用/再接收增加无关.
结论:
- 大多数住院的儿科喘患者接受了联合类固醇治疗.
- 尽管严重程度有差异,但组合疗法和德克萨米他单一疗法显示出与普得尼松单一疗法相比的再入院率.
- 类固醇选择没有显著影响短期ED再利用率或医院再入院率.
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