干重基础上的THC含量:对大麻合法性的影响
Frank J Sikora1, Solomon K Kariuki1, Robert C Pearce2
1University of Kentucky, Division of Regulatory Services, 103 Regulatory Service Bldg, Lexington, KY 40546, USA.
Journal of AOAC International
|June 24, 2024
概括
在70°C下24小时干燥大麻是最快速的方法,可以在不影响总THC (THCTotal) 水平的情况下准备它进行研磨. 在干重的基础上计算THCTotal,与湿重分析相比,没有显著的优势.
科学领域:
- 农业科学 农业科学
- 分析化学 分析化学
背景情况:
- "2018年农业法案"依法将大麻 (Cannabis sativa L.) 定义为其四大麻素 (THC) 度,在干重基础上不超过0.3%.
- 总THC (THCTotal) 包括该化合物的酸性 (Δ9-THCA) 和中性 (Δ9-THC) 形式.
研究的目的:
- 为了确定最佳的温度和质量,快速准备新鲜的麻磨,同时保持THCTotal完整性.
- 分析能力测试数据,以比较THCT总含量测量在干燥和湿的基础上.
主要方法:
- 新鲜的大麻样品 (150g和400g) 在50°C,60°C和70°C的温度下经过冷干燥或热处理,长达72小时.
- 用AOAC 934.01确定水分含量,使用LC/MS或GC/FID量化THCTotal.
- 在12个分析样本上分析了来自20-67个实验室 (2020-2022) 的技能测试数据.
主要成果:
- 发现的最有效的干燥方法是24小时在70°C下用150克大麻干燥,在干燥量基础上没有改变THCTotal.
- 熟练测试样本显示了5.8%-11.4%的湿度和0.144%-0.399%的THCTotal (湿重量基础).
- 干重与湿重的THCTotal之间的差异很小 (0.002%-0.027%),只有一个样本有显著的变化.
结论:
- 在70°C下24小时干燥大麻是一种有效的方法,可以在不影响THCTotal含量的情况下准备它进行研磨.
- 基于干重的基础上计算THCTotal是不必要的,因为最小的差异,实验室间的变化和潜在的烯损失.
相关概念视频
Moisture Content and Bulking of Aggregate
136
The moisture content of aggregates is a crucial factor in construction, particularly in concrete mixing, as it influences the total water required in the mix. Moisture content represents the water coated on the exterior surface of the aggregate existing in a saturated and surface-dry condition. The total water content of a moist aggregate is the sum of its moisture content and water absorption.
When aggregates are exposed to rain or sit in stockpiles, they absorb moisture, which must be...
When aggregates are exposed to rain or sit in stockpiles, they absorb moisture, which must be...
136
Hess's Law
45.0K
There are two ways to determine the amount of heat involved in a chemical change: measure it experimentally, or calculate it from other experimentally determined enthalpy changes. Some reactions are difficult, if not impossible, to investigate and make accurate measurements for experimentally. And even when a reaction is not hard to perform or measure, it is convenient to be able to determine the heat involved in a reaction without having to perform an experiment.
45.0K
Therapeutic Index
4.2K
The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to...
4.2K
Physical Properties of Alkanes
10.9K
Alkanes are nonpolar molecules due to the presence of only carbon and hydrogen atoms. The electronegativity difference between carbon and hydrogen is minimal, and hence alkanes have a zero dipole moment. This leads to the presence of only dispersion forces between the molecules. The strength of dispersion forces is dependent on the surface area of the molecules on which they act. Since the surface area increases with the molecular length for straight-chain alkanes, the dispersion forces also...
10.9K
Drug Regulation
1.4K
Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
1.4K
Physical Properties of Ethers
7.0K
Overview
An ether molecule has a net dipole moment due to the polarity of C–O bonds. Subsequently, boiling points of ethers are lower than those of alcohols of comparable molecular weight and slightly higher than those of hydrocarbons of comparable molecular weight (Table 1).
Ethers can act as hydrogen bond acceptors, making them more water-soluble than hydrocarbons, but since ethers cannot act as hydrogen bond donors, they are much less soluble in water than alcohols. Ethers are considered...
An ether molecule has a net dipole moment due to the polarity of C–O bonds. Subsequently, boiling points of ethers are lower than those of alcohols of comparable molecular weight and slightly higher than those of hydrocarbons of comparable molecular weight (Table 1).
Ethers can act as hydrogen bond acceptors, making them more water-soluble than hydrocarbons, but since ethers cannot act as hydrogen bond donors, they are much less soluble in water than alcohols. Ethers are considered...
7.0K


