在希腊COVID-19大流行期间的Clostridioides difficile感染流行病学
Theodoros Karampatakis1, Eleni Kandilioti1, Helen Katsifa1
1Microbiology Department, Papanikolaou General Hospital, 570 10, Thessaloniki, Greece.
Future microbiology
|June 24, 2024
概括
在COVID-19期间,希腊一家医院的Clostridioides difficile感染 (CDI) 发生率增加. 然而,导致这些感染的关键特征和菌株基本保持不变.
科学领域:
- 传染性疾病 传染性疾病
- 流行病学 流行病学
- 微生物学 微生物学
背景情况:
- 困难菌感染 (CDI) 构成了医疗保健方面的重大挑战.
- COVID-19大流行改变了医疗保健实践,并可能影响了CDI流行病学.
- 了解大流行期间的CDI趋势对于感染控制至关重要.
研究的目的:
- 确定CDI的发病率和流行病学特征.
- 在COVID-19大流行期间,在希腊第三级医院调查CDI模式.
- 为了确定流行的Clostridioides difficile菌株及其毒素概况.
主要方法:
- 从2021年10月到2022年4月进行了前性观察队列研究.
- 125个Clostridioides difficile分离物从住院患者中收集.
- 使用PCR检测毒素基因 (tcdA,tcdB,cdtA,cdtB) 和tcdC基因.
主要成果:
- CDI的发病率上升到每10,000个病床日中有13.1个感染.
- 最常见的PCR核型是RT181 (73.6%),RT126 (8.0%) 和RT017 (7.2%).
- 与高病毒性RT027相关的RT181是主要的菌株.
结论:
- 在研究期间,CDI发病率显著增加.
- 尽管感染率上升,但CDI的整体流行病学仍然稳定.
- 超病毒性菌株在医院环境中仍然是一个主要问题.
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