创伤幸存者与或没有可能的创伤后应激障碍的肠道细菌的差异
Timothy J Geier1, Samantha N Atkinson2, Amy Y Pan3
1Department of Surgery, Division of Trauma and Acute Care Surgery, Medical College of Wisconsin, Milwaukee, WI, United States of America.
Journal of affective disorders
|June 24, 2024
概括
肠道微生物组可能在创伤后应激障碍 (PTSD) 中发挥作用. 在可能患有PTSD的个体中,特定的细菌类Actinobacteriota和Verrucomicrobiota被改变,这表明PTSD亚型的微生物特征.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
背景情况:
- 创伤后应激障碍 (PTSD) 是创伤后常见的心理健康状况.
- 影响PTSD异质性的生物学因素仍未得到充分研究.
- 肠道微生物对心理健康的影响需要对PTSD进行调查.
研究的目的:
- 为了研究可能患有PTSD的成年人肠道微生物组合.
- 探索特定细菌种群和PTSD症状集群之间的关系.
- 识别与不同PTSD呈现相关的微生物特征.
主要方法:
- 与可能患有PTSD的成年人 (n=24) 与对照组 (n=24) 的细菌组成进行比较,创伤后2 - 4年.
- 利用16S rRNA测序和生物信息分析来检测微生物多样性和丰富性.
- 评估了细菌种类和PTSD症状集群之间的关联 (负情绪/认知,过度兴奋).
主要成果:
- 两组之间没有观察到总体微生物社区结构的显著差异.
- 可能的PTSD组显示了Actinobacteriota的减少和Verrucomicrobiota系的丰富度的增加.
- 特定的种群,Prevotella和Ruminococcaceae,表现出与负面情绪和过度兴奋症状的差异性关联.
结论:
- 微生物特征与可能的PTSD亚型有关.
- 肠道微生物组可能会调解异构的创伤精神病理.
- 识别微生物相关物可以为PTSD症状概况提供个性化的精神生物干预措施.
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