在怀孕期中期的人类脑脑中,与未被破坏的胸膜分片模式一起改变了胸膜皮层管道的生长轨迹
Sheng-Min Huang1, Kuan-Hung Cho2, Koping Chang3
1Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Zhunan, Miaoli County 350, Taiwan.
Neurobiology of disease
|June 24, 2024
概括
这项研究使用扩散MRI来检查胎儿大脑中的乳头皮层 (TC) 连接. 尽管整体模式相似,但lissencephaly大脑显示TC纤维较少,皮质入侵减少,影响大脑发育.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 医疗成像医学成像
背景情况:
- 脑皮层 (TC) 连接对大脑功能至关重要,在胎儿发育过程中形成.
- 先天性新皮质异常 (如脑病) 对人类TC连接的影响在很大程度上是未知的.
研究的目的:
- 为了研究脑病对死后胎儿大脑中乳皮层 (TC) 纤维发育的影响.
- 评估在固定胎儿大脑组织中扩散MRI纤维通道图的可行性.
主要方法:
- 扩散MRI纤维通道扫描是在用甲固定的死后胎儿大脑上进行的,比较了脑病例与年龄相匹配的正常对照.
- 在妊娠15周,23周和26周 (GW) 分析了正常的胎儿大脑,以绘制正常的TC通道发育图.
主要成果:
- 虽然thalamic亚区域的总体拓模式相似,但lissencephaly大脑表现出减少/无组织的TC纤维和光学辐射.
- 皮质板中TC纤维的入侵在脑性脑中显著减少,特别是在中央附近.
- 正常的胎儿大脑发育显示出动态体积变化和逐渐的TC侵袭皮质板.
结论:
- 在固定胎儿大脑中,扩散MRI纤维通道学是可行的,以研究TC通道的发育.
- 脱脑症与显著的白质结构变化和受损的TC纤维发育有关.
- 这项研究突出显示了质体和新皮质的协调发育,以及脑造成的干扰.
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