在成年人注意力缺陷/多动症障碍 (ADHD) 管道中的治疗方法
Guilherme Fusetto Veronesi1, Alessandra Gabellone2, Anneka Tomlinson3
1Southern Health NHS Foundation Trust, UK.
Neuroscience and biobehavioral reviews
|June 24, 2024
概括
在开发中的新型ADHD治疗方法显示有效性和耐受性有限. 纳法丁显示出一些益处,但目前没有管道干预措施与成人注意力缺陷/多动症障碍 (ADHD) 的现有治疗方法相匹配.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 临床试验 临床试验
背景情况:
- 注意缺陷/多动障碍 (ADHD) 显著影响成年人的功能.
- 现有的成人多动症治疗方法,主要是兴奋剂和阿托莫克赛丁,具有局限性.
- 需要新的,有效的,耐受良好的ADHD疗法.
研究的目的:
- 审查成年ADHD的药理和非药理治疗的管道.
- 确定正在进行的或已完成的2期或3期随机对照试验 (RCT) 针对新型成人ADHD干预措施.
- 评估新兴ADHD治疗方法的疗效和耐受性.
主要方法:
- 搜索了clinicaltrials.gov和clinicaltrialsregister.eu (2010-2023) 在ADHD成年人中进行的2/3期RCT.
- 包括试验评估干预措施没有目前的监管批准.
- 分析了主要疗效终点的报告结果.
主要成果:
- 确定了90个符合条件的RCT;只有24个 (27%) 报告了分析的结果.
- 纳法丁 (Centanafadine) 显示出复制的疗效 (效果大小小) 和合理的耐受性.
- 没有其他干预措施在多个RCT中显示出一致的有效性.
- ADHD 治疗的整体管道是不够的.
结论:
- 目前的研究表明,缺乏新的成人多动症治疗方法,这些治疗方法在有效性或耐受性方面与现有的选择相匹配.
- 百纳法丁显示有前途,但需要进一步验证.
- 开发和测试额外的有效和耐受性良好的ADHD治疗方法至关重要.
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