估计的骨矿物质密度和白质超强度:一个双向的门德尔随机化研究
Xiaoling Li1, Xiaoju Wu2, Guoqiu Zhou2
1Department of Neurology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China; Guangxi Key Laboratory of Precision Medicine in Cardio-cerebrovascular Diseases Control and Prevention, Nanning, China.
Bone
|June 24, 2024
概括
低骨矿物质密度 (BMD) 会增加老年人白质过强度 (WMH) 的风险. 然而,白质超强度似乎不会对骨矿物质密度产生因果关系.
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 遗传学 是一个遗传学.
背景情况:
- 白质超强度 (WMH) 与老年人骨矿物质密度 (BMD) 降低和骨折风险增加有关.
- 骨硬化和WMH之间的因果关系尚不清楚.
- 门德尔随机化 (MR) 是一种强大的方法,用于调查特征之间的因果关系.
研究的目的:
- 使用双向门德尔随机化 (MR) 方法调查估计的BMD (eBMD) 和WMH之间的潜在因果关系.
- 要确定减少的BMD是否导致WMH或WMH是否影响BMD.
主要方法:
- 使用公开可用的全基因组关联研究 (GWAS) 数据进行了两样双向MR分析.
- 反变量加权 (IVW) 方法是主要的分析方法.
- 使用MR-Egger回归和MR-PRESSO来评估和纠正横向形变异.
主要成果:
- 核磁共振分析显示了eBMD对WMH的因果作用 (IVW OR = 0.938,p = 0.020),表明较低的eBMD增加了WMH风险.
- 在反向MR分析中,没有发现WMH对eBMD的显著因果作用 (IVW OR = 0.979,p = 0.109).
- 对异质性和性质的测试 (MR-Egger,MR-PRESSO) 表明因果估计是可靠的.
结论:
- 低估计的BMD是老年人白质强度过高的因果风险因素.
- 没有证据支持白质超强度在影响骨矿物质密度方面的因果作用.
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