治疗皮肤疾病的局部应用疗法:过去,现在和未来
Marc Brown1, Adrian Williams2, Robert P Chilcott2
1MLBT Investments and Consultancy, Aylesbury, United Kingdom (M.Br.); MedPharm Ltd, Guildford, United Kingdom (M.Br., B.B., C.E., J.H., F.G.); Reading School of Pharmacy, Reading, United Kingdom (A.W.); School of Life and Medical Sciences, University of Hertfordshire, Hatfield, United Kingdom (R.P.C., W.J.M.); MedPharm Ltd, Durham. North Carolina (J.L., L.A., C.B.); Medicine Development and Supply, GlaxoSmithKline R&D, Stevenage, United Kingdom (M.Be.); Department of Dermatology, CUF Tejo Hospital, Lisbon, Portugal (R.V.); Centro de Investigação Interdisciplinar Egas Moniz, Egas Moniz School of Health and Science, Monte de Caparica, Portugal (M.M.); and Department of Chemistry, Coimbra Chemistry Center, University of Coimbra, Coimbra, Portugal (M.M.) marc@mlbtinvestments.com.
本综述详细介绍了局部医学的发展,包括皮肤生物学,疾病治疗,配方和患者因素. 它旨在指导科学家为各种皮肤疾病创造改进的局部疗法.
科学领域:
- 皮肤病学和制药科学 皮肤病学和制药科学
- 专注于局部药物输送系统和皮肤疾病管理.
背景情况:
- 审查局部药物输送的历史以及皮肤的结构和功能.
- 解释了通过皮肤吸收药物的途径及其固有的局限性.
研究的目的:
- 巩固关键的生物,制药和临床知识,用于开发新的局部药物.
- 帮助科学家做出有关局部治疗开发的明智决策.
主要方法:
- 皮肤生物学,药理学和临床应用的综合文献综述.
- 分析流行皮肤疾病和当前的局部治疗策略.
- 检查当前产品的开发,制造和风险减轻.
主要成果:
- 对自身免疫/炎症性疾病,感染,癌症和遗传性皮肤疾病的局部治疗方法的详细讨论.
- 突出了当前产品开发,制造和以患者为中心的考虑方面的挑战.
- 确定了提高局部药物的疗效和扩大治疗应用的未来方向.
结论:
- 该综述提供了一个全面的概述,对于在局部药物开发中做出明智决策至关重要.
- 强调考虑活性成分,配方,患者偏好和未来创新的重要性.
相关概念视频
Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Drug Delivery: Miscellaneous Routes
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Local Anesthetics: Common Agents and Their Applications
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
Skin Diseases and Disorders
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Routes of Drug Administration: Overview
Enteral administration refers to drugs absorbed through the gastrointestinal tract. They can be swallowed (perorally), placed under the tongue (sublingually), or on the inner lining of the cheeks (buccally). Perorally administered drugs take time to be absorbed and have a slower onset of action. The rectal route is another form of enteral administration, which allows for...
Tumor Immunotherapy


