乙烯氧化物暴露与美国成年人抑郁症的关联
Meng Wang1, Chao Liu2, Quan Liu3
1Department of Oncology, Affiliated Hospital of Jiangnan University, Wuxi, 214122, China.
Scientific reports
|June 24, 2024
概括
乙烯氧化物 (EO) 暴露与抑郁症风险增加有关. 这种关联部分归因于诸如白细胞和中性粒细胞等炎症因素.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 精神病学是一个精神病学.
背景情况:
- 乙烯氧化物 (EO) 是一种具有已知的健康风险的有机反应化合物.
- 易氧暴露对抑郁症的具体影响尚未得到充分证实.
- 了解这种联系对于公共卫生至关重要.
研究的目的:
- 调查乙烯氧化物暴露与抑郁风险之间的关联.
- 探索炎症因子在这种关系中的调解作用.
- 确定协会是否遵循特定的模式.
主要方法:
- 使用NHANES数据 (2013-2016) 的横截面研究,共有2884名参与者.
- 对EO (HbEO) 水平的log10转化血红蛋白添加物的分析,分为四分位数.
- 后勤回归和调解分析以评估EO-抑郁链接和炎症途径.
主要成果:
- 抑郁症患者的HbEO水平较高.
- 在HbEO的最高四分位数中,抑郁症的风险显著增加 (OR=2.21).
- 在EO水平和抑郁症患病率之间观察到非线性U形模式.
- 白细胞 (14.70%) 和中性粒细胞 (12.55%) 显著调解了这种关联.
结论:
- 乙烯氧化物暴露与抑郁症的风险增加有关.
- 炎症标志物,特别是白细胞和中性粒细胞,部分调解这种关联.
- 这些发现凸显了EO暴露的潜在神经炎症影响.
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